Related Experiment Videos
[Research Progress in Venetoclax-Based Combination Therapy in Acute Myeloid Leukaemia--Review]
1Department of Hematology, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, Anhui Province, China.
None:
Acute myeloid leukemia (AML) can be transformed by the malignant transformation of hematopoietic progenitor cells at different stages of normal myeloid cell differentiation and development, thus leading to infection, anemia, bleeding symptoms. It is a common highly heterogeneous hematologic malignancy, the incidence of which is on the rise year by year. The treatment of AML includes chemotherapy, hematopoietic stem cell transplantation and targeted therapy, etc. However, due to the highly heterogeneous nature of AML and the easy recurrence, the treatment is difficult and the cure rate is low. In recent years, combination therapy based on venetoclax has become one of the important research directions for the treatment of AML, and its efficacy has gradually received the attention of clinical researchers. This paper reviews the mechanism of action of venetoclax and its application in the current treatment of AML. Through an in-depth discussion of venetoclax and its combination therapy AML related clinical trials, the emergence of resistance mechanisms to venetoclax and potential strategies to overcome its resistance are summarized.
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Treatment Resistent Cancers
Treatment Resistant Cancers
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Venous Thrombosis III: Interprofessional Care