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[Research Progress of CAR-T Cell Therapy in Autoimmune Diseases --Review]
Qiang Xiong1, Fei Li1,2,3
1Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
None:
Chimeric antigen receptor T (CAR-T) cell therapy has achieved significant success in the field of hematologic oncology. Considering the similarities in the origin and circulatory distribution between hematopoietic tumor cells and autoantigen-specific immune cells, research has commenced to apply CAR-T cell therapy to autoimmune diseases, yielding encouraging preliminary findings. This article reviews the mechanisms of action and clinical research data of CAR-T cells in diseases such as systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, myasthenia gravis, and rheumatoid arthritis in recent years, with the aim of providing a broader perspective for the future application of CAR-T cells in the field of autoimmune diseases.
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