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Biopharmaceutical Factors Influencing Drug Product Design: Overview

Biopharmaceutical Factors Influencing Drug Product Design: Overview

Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though pharmacologically...

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

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Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...

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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

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Multi-Component Analysis by Chemometric Techniques: Advances and Applications for Solid Dosage Form.

Shilpa Sahu¹, Shiv Shankar Shukla¹, Ravindra Kumar Pandey¹

¹Department of Pharmacy, Columbia Institute of Pharmacy, Near Vidhan Sabha, Mandhar, Raipur (Chhattisgarh), 493111, India.

Combinatorial Chemistry & High Throughput Screening

|June 2, 2026

Summary

Chemometric multivariate techniques offer accurate, non-destructive analysis for complex chemical data. These methods streamline pharmaceutical analysis, improving quality control with cost-effective and trustworthy results.

Keywords:

Chemometric classical least squares (CLS).multivariate partial least squares (PLS)principal component regression (PCR)simultaneous estimation

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Last Updated: Jun 3, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

Standardized Identification of Compound Structure in Tibetan Medicine Using Ion Trap Mass Spectrometry and Multiple-Stage Fragmentation Analysis

Standardized Identification of Compound Structure in Tibetan Medicine Using Ion Trap Mass Spectrometry and Multiple-Stage Fragmentation Analysis

Published on: March 17, 2023

Area of Science:

Analytical Chemistry
Data Science

Background:

Chemometric multivariate techniques are statistical methods for extracting information from complex datasets.
They are crucial for analyzing multivariate data common in spectroscopy and chromatography.

Purpose of the Study:

To highlight the potential of chemometric techniques in pharmaceutical analysis.
To demonstrate their ability to improve quality control and streamline workflows.

Main Methods:

A literature survey of 150 articles was conducted.
Chemometric multivariate methods were applied to analyze complex data.

Main Results:

Chemometric methods enable accurate, precise, and non-destructive analysis, overcoming limitations of univariate approaches.
They accurately quantify active pharmaceutical ingredients (APIs) in multicomponent formulations with overlapping spectra.
These techniques are cost-effective, require minimal sample handling, and provide trustworthy results.

Conclusions:

The study demonstrated the efficacy of chemometric methods using UV-Vis spectroscopy and chromatographic data.
Results showed high predictive ability and minimal interference from excipients.