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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

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  3. Metabolite-based Biomarkers For Autism Spectrum Disorder: Current Research Progress.
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  3. Metabolite-based Biomarkers For Autism Spectrum Disorder: Current Research Progress.

Related Experiment Video

Strategies for Assessing Autistic-Like Behaviors in Mice
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Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

Metabolite-Based Biomarkers for Autism Spectrum Disorder: Current Research Progress.

Hong Zhou1,2,3, Wenwen Tang1,2,3, Yuemei Zhang1,2,3

  • 1National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430030, Hubei, China.

Current Molecular Medicine
|June 2, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Metabolic pathway dysregulation is a key factor in autism spectrum disorder (ASD). This review synthesizes metabolic biomarkers across five domains to identify potential early detection and intervention targets for ASD.

Keywords:
Autism spectrum disordergut microbiota dysbiosis.immune dysregulationmitochondrial dysfunctionneurotransmitter dysfunctionoxidative stress

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Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
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Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

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Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Area of Science:

  • Neuroscience
  • Metabolomics
  • Biochemistry

Background:

  • Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with increasing global prevalence.
  • Its etiology involves genetic, environmental, and interactive factors, with metabolic pathway dysregulation emerging as a significant contributor.
  • Current research on metabolic disturbances in ASD is fragmented, necessitating a systematic review.

Purpose of the Study:

  • To systematically synthesize and evaluate metabolic biomarkers associated with ASD.
  • To categorize these biomarkers into five interrelated mechanistic domains: neurotransmitter dysfunction, immune dysregulation, mitochondrial dysfunction, oxidative stress, and gut microbiota dysbiosis.
  • To explore potential cross-talk between these pathways and identify candidate biomarkers for early detection and intervention.

Main Methods:

  • Systematic literature review and synthesis of existing research on metabolic biomarkers in ASD.
  • Categorization of biomarkers based on core pathobiological functions into five mechanistic domains.
  • Integration of evidence to delineate metabolite alterations and inter-pathway communication.

Main Results:

  • Metabolite abnormalities are identified within neurotransmitter, immune, mitochondrial, oxidative stress, and gut microbiota pathways in ASD.
  • Evidence suggests significant cross-talk and interrelationships between these metabolic domains in ASD pathogenesis.
  • Specific metabolite alterations serve as potential biomarkers for ASD.

Conclusions:

  • Metabolic dysregulation is a critical factor in ASD pathogenesis, impacting multiple biological systems.
  • The identified metabolic biomarkers offer potential for early ASD detection and the development of novel therapeutic strategies.
  • An integrative approach to understanding metabolic disturbances is crucial for advancing ASD research and clinical practice.