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Related Concept Videos

Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Transmission-based Precautions I: Contact, Enteric, and Droplets01:17

Transmission-based Precautions I: Contact, Enteric, and Droplets

Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...

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Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
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Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

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Bridging the Gap Between General and Transplant Infectious Disease Practice.

Jeremey Walker1, Emily Eichenberger2, Steven Pergam3

  • 1Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|June 2, 2026
PubMed
Summary
This summary is machine-generated.

The number of immunocompromised patients is increasing due to advances in medicine. This requires broader infectious disease expertise beyond specialized centers to manage opportunistic infections in these growing patient populations.

Keywords:
clinical practiceimmunocompromised hostmedical educationopportunistic infection

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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

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Last Updated: Jun 3, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Area of Science:

  • Immunology
  • Infectious Diseases
  • Transplantation Medicine

Background:

  • The population of iatrogenic immunocompromised individuals is increasing due to improved management of conditions like cancer, autoimmune diseases, and end-organ dysfunction.
  • Enhanced survivorship leads to a greater number of immunocompromised patients across all healthcare systems, necessitating broader access to specialized care.
  • Expertise in immunocompromised host infectious diseases and transplant infectious diseases (TID) is currently concentrated in urban academic centers, creating a gap in community healthcare settings.

Purpose of the Study:

  • To review three case studies highlighting common immunosuppressed patient groups encountered in any health system: solid organ transplantation, hematologic malignancy, and autoimmune disease.
  • To describe common illness scripts and key management considerations for opportunistic pathogens in these patient groups.
  • To provide high-yield references supporting clinical care for immunocompromised patients and discuss the evolving landscape of infectious diseases training.

Main Methods:

  • Case review of three distinct patient populations with iatrogenic immunosuppression.
  • Discussion of common opportunistic pathogens and their management.
  • Identification of key references and training needs in the field.

Main Results:

  • The cases illustrate common scenarios and management strategies for opportunistic infections in solid organ transplant recipients, patients with hematologic malignancy, and those with autoimmune disease.
  • Key considerations for managing opportunistic pathogens in these diverse immunocompromised groups are outlined.
  • Essential references for clinicians and fellows are provided, alongside a discussion on training standards.

Conclusions:

  • Immunocompromising conditions are a substantial and expected patient population in all healthcare settings, not a niche concern.
  • There is a critical need to expand infectious disease expertise and training to meet the growing demand for managing immunocompromised patients.
  • Collaboration among societies and the recruitment of future physicians are essential to address the increasing need for specialized care in immunocompromised host infectious diseases.