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Updated: Jun 3, 2026

Preparation of a Corannulene-functionalized Hexahelicene by Copper(I)-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
Generation of Donor/Donor Copper Carbenes through Copper-Catalyzed Cycloisomerization/Oxidation of Vinyl-Allenes:
Kua-Fei Wei1, Ning Wang1, Pu-Hui Xie1
1College of Science, Henan Agricultural University, Zhengzhou, China.
Abstract:
Transition-metal-catalyzed cycloisomerization of vinyl-allenes has attracted enormous attention over the past decades, and multitudinous efficient synthetic strategies have been discovered based on this methodology. However, the generation of metal carbenes in these reactions is mostly limited to the noble-metal catalysts (Au and Pt). Here we show that non-noble-metal catalyst (Cu) enable the catalytic cycloisomerization/oxidation of vinyl-allenes by generating α-alkyl alkenylcopper carbenes. This protocol leads to the practical and controllable construction of various valuable cyclopentenones in mostly good to excellent yields.
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