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Related Experiment Video

Updated: Jun 3, 2026

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
10:15

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

Kidney Selective Bcl2 Inhibitor Delivery Improves Fibrosis Treatment.

Humayra Afrin1,2, Sayantani Chakraborty3, Md Nafiujjaman4

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, Texas 79902, United States.

ACS Applied Bio Materials
|June 2, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed a targeted nanoparticle therapy for kidney fibrosis. This novel treatment effectively reduced fibrosis markers and promoted kidney cell death, showing potential to reverse disease pathology.

Keywords:
fibrosiskidneynanoparticlenavitoclaxtargeted therapy

Related Experiment Videos

Last Updated: Jun 3, 2026

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
10:15

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Renal Medicine

Background:

  • Kidney fibrosis is a severe, often asymptomatic disease with limited treatment options.
  • Current treatments for advanced kidney fibrosis include dialysis or transplantation.
  • There is an urgent need for effective therapies to combat kidney fibrosis.

Purpose of the Study:

  • To develop a nanoparticle-mediated therapeutic strategy for kidney fibrosis.
  • To target kidney fibrosis using nanoparticles loaded with a Bcl-2 inhibitor (Navitoclax) and linked to an AT2 receptor-targeting peptide.
  • To evaluate the therapeutic efficacy of this targeted nanoparticle formulation.

Main Methods:

  • Modification of poly(lactic-co-glycolic acid) (PLGA) nanoparticles with an AT2 peptide and loading with Navitoclax.
  • In vitro and in vivo studies to assess the efficacy of targeted nanoparticles (TNP/Navi) compared to free Navitoclax or non-targeted nanoparticles (NP/Navi).
  • Assessment of Bcl-2 expression, apoptosis, alpha-smooth muscle actin (α-SMA), connective tissue growth factor (CTGF), kidney morphology, and collagen deposition.

Main Results:

  • Targeted nanoparticles (TNP/Navi) significantly reduced Bcl-2 expression and increased apoptosis compared to other groups.
  • A notable decrease in α-SMA and CTGF was observed in vitro and in vivo with TNP/Navi treatment.
  • Treated kidneys showed preserved normal morphology and reduced collagen deposition, indicating fibrosis reversal.

Conclusions:

  • AT2 receptor-targeted nanoparticles loaded with Navitoclax demonstrate significant therapeutic potential for kidney fibrosis.
  • This nanoparticle-mediated apoptosis upregulation can reverse kidney fibrosis pathology.
  • The developed formulation offers a promising new avenue for treating kidney fibrosis.