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Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
Pediatric Liver Transplantation: A Single-Center Experience in the Intensive Care Unit
Ibrahim Bingol1, Tonguc Utku Yilmaz2, Ozge Umur1
1Department of Pediatric Intensive Care, Acıbadem Mehmet Ali Aydınlar University, İstanbul, Türkiye.
Turkish Archives of Pediatrics
|June 2, 2026
Summary
Pediatric liver transplantation outcomes in Türkiye show acceptable survival rates, but prolonged intensive care unit stays increase mortality risk. Infectious and neurological complications require careful management in pediatric liver transplant recipients.
Area of Science:
- Pediatric Hepatology
- Transplant Surgery
- Critical Care Medicine
Background:
- Liver transplantation is the primary treatment for pediatric end-stage liver disease.
- Recent advancements have improved survival rates in pediatric liver transplant patients.
Purpose of the Study:
- To evaluate outcomes of pediatric liver transplantation at a single center in Türkiye.
- To identify factors influencing mortality in pediatric liver transplant recipients.
Main Methods:
- Retrospective study of 140 pediatric patients (<18 years) undergoing liver transplantation (2015-2023).
- Data collected on demographics, indications, complications, PICU course, retransplantation, and mortality.
- Multivariate logistic regression used to identify mortality predictors.
Main Results:
- Biliary atresia and metabolic diseases were leading indications.
- Postoperative complications occurred in 42.1%, with infections being most common.
- Overall mortality was 14.3%, with sepsis and CNS complications as leading causes of death.
- Prolonged Pediatric Intensive Care Unit (PICU) stay was the sole independent predictor of mortality.
Conclusions:
- Outcomes align with international standards, showing acceptable complication and survival rates.
- Infectious and neurological complications highlight the need for robust infection control and early intervention.
- Optimized intensive care and further research into long-term graft function are recommended.
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