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Updated: Jun 4, 2026

Virtual Agent for Real-Time Motivational Interviewing by Integrating Adaptive Nonverbal Behavior and Language Models
Published on: December 23, 2025
Use of the Dynamic Systems Development Method to Inform Technology-Assisted Motivational Interviewing (TAMI) for
Brian Borsari1,2, Joannalyn Delacruz1,2, Ahson Saiyed3
1San Francisco VA Medical Center, 4150 Clement St (116B), San Francisco, CA, 94121, United States, 1 415-221-4810 ext 26078.
Background:
Smoking continues to be a leading cause of preventable morbidity and mortality, and more than 480,000 Americans die annually due to smoking-related illness attributable to smoking and secondhand smoke. More advanced, responsive, and tailored digital interventions using machine learning and artificial intelligence may be a valuable tool for successful smoking cessation referrals.
Objective:
This study used the dynamic systems development method to incorporate patient and consumer sources of conversational data to develop a technology-assisted motivational interviewing (TAMI) chatbot, a digital agent using machine learning models to deliver motivational interviewing (MI) for tobacco cessation.
Methods:
During the functional model iteration phase, user-centered design interviews with smokers (n=3) informed the creation of TAMI. The design and build phase involved the use of existing datasets to guide the incorporation of MI-consistent utterances, language recognition, and topic classification to guide a discussion about smoking, and providing a tailored quit plan if indicated. During the implementation phase, user experience interviews with randomly selected participants (n=9) in a pilot trial discussed their experiences with TAMI.
Results:
User-centered design interviews indicated a desire for a chatbot that was engaging and adaptable to personal interests in quitting smoking. Inductive analysis of user experience interviews revealed that anonymity, regular reminders, and a humanized experience facilitated engagement with TAMI, but technical glitches, chatbot misunderstandings, and issues with rapport were barriers to engagement.
Conclusions:
Informed by user input and patient and consumer datasets, TAMI can use MI skills to elicit change talk and/or accurately evaluate readiness for tobacco cessation. Further development will enhance TAMI's ability to seamlessly engage with users when discussing behavior change and assist underserved populations achieve improvements in a variety of health behavior goals.
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