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Related Concept Videos

Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lenz's Law01:15

Lenz's Law

The direction in which the induced emf drives the current around a wire loop can be found through the negative sign. However, it is usually easier to determine this direction with Lenz's law, named in honor of its discoverer, Heinrich Lenz (1804–1865). Lenz's law states that the direction of the induced emf drives the current around a wire loop always to oppose the change in magnetic flux that causes the emf.
If a bar magnet is moved toward a coil such that the magnetic flux through the coil...

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Updated: Jun 4, 2026

Semi-High Throughput Screening for Potential Drought-tolerance in Lettuce (Lactuca sativa) Germplasm Collections
06:35

Semi-High Throughput Screening for Potential Drought-tolerance in Lettuce (Lactuca sativa) Germplasm Collections

Published on: April 17, 2015

The Lettuce Expression Browser: from lab to LEB.

Dirk-Jan M van Workum1, Esther S van den Bergh2, Siddhant S Shetty3

  • 1Bioinformatics Group, Wageningen University and Research, Droevendaalsesteeg 1, 6708 PB, Wageningen, The Netherlands.

The Plant Journal : for Cell and Molecular Biology
|June 2, 2026
PubMed
Summary
This summary is machine-generated.

We created the Lettuce Expression Browser (LEB), a new tool mapping gene activity across lettuce tissues and conditions. This resource aids research into lettuce development, stress responses, and crop improvement.

Keywords:
AsteraceaeLactuca sativaLettuce Expression Browser (LEB)comparative gene expressiongene expression atlaslettucetissue‐specific expressiontranscriptomics

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Published on: May 2, 2018

Area of Science:

  • Plant science
  • Genomics
  • Bioinformatics

Background:

  • Lettuce (Lactuca sativa L.) is a key crop with growing genomic resources.
  • Existing gene expression data lacks tissue-specific resolution and clear visualization.
  • This limits functional genomics studies in the Asteraceae family.

Purpose of the Study:

  • To develop a high-resolution gene expression resource for lettuce.
  • To provide an intuitive platform for exploring gene activity across tissues and conditions.
  • To support research in lettuce development, stress responses, and crop improvement.

Main Methods:

  • Developed the Lettuce Expression Browser (LEB) platform.
  • Integrated transcriptomic data from diverse lettuce tissues, developmental stages, and abiotic stress treatments (salt, far-red).
  • Visualized expression data using the ggPlantmap R package.

Main Results:

  • Created comprehensive, high-resolution gene expression maps for cultivated and wild lettuce species.
  • The LEB platform offers an intuitive interface for exploring gene expression patterns.
  • The resource visualizes expression across organs, tissues, and developmental stages.

Conclusions:

  • The Lettuce Expression Browser (LEB) is a valuable public resource for lettuce functional genomics.
  • It enhances understanding of lettuce development, abiotic stress responses, and evolutionary genomics.
  • LEB will facilitate lettuce research and crop improvement efforts.