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Updated: Jun 4, 2026
Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
Interfacial capacitance using nanocomposite sensors as a deterministic bioelectrochemical information for complex
Itthipon Jeerapan1, Kanyawee Kaewpradub2, Patcharawat Charoen-Amornkitt3
1Division of Physical Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand; Center of Excellence for Trace Analysis and Biosensor, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand; Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand; The ijE Electrochemistry for All Laboratory, Hat Yai, Songkhla, 90110, Thailand.
This study reveals interfacial capacitance as a key indicator for detecting water adulteration in milk. This novel approach offers rapid, label-free biosensing in complex biological samples.
Area of Science:
- Electrochemistry
- Biosensing
- Materials Science
Background:
- Electrochemical diagnostics rely on interfacial event characterization.
- Conventional models struggle with biological matrix complexity.
- Heterogeneous interfaces in biofluids complicate capacitance analysis.
Purpose of the Study:
- To establish interfacial capacitance as quantifiable biomatrix information.
- To enable rapid, label-free detection of water adulteration in milk.
- To develop a mathematical framework for analyzing interfacial capacitance in complex samples.
Main Methods:
- Utilized high-density multiwalled carbon nanotube paste electrodes.
- Derived a constitutive model linking capacitance to water content and scan rate.
- Analyzed signal components previously considered noise.
Main Results:
- Interfacial capacitance accurately reflects biomatrix state.
- Developed model predicts water adulteration with high correlation (R²=0.9962).
- Identified noise components as crucial for detecting biomatrix variations.
Conclusions:
- Interfacial capacitance is an information-rich variable for bioelectroanalysis.
- This redefinition enables robust biosensing in dense biochemical environments.
- The findings pave the way for advanced diagnostics in complex biological samples.
