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Related Experiment Video

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Volumetric absorptive microsampling device for forensic Toxicologic screening: A case report as proof-of-concept.

Romain Magny1, Jessica Adell2, Laurence Labat1

  • 1Laboratoire de Toxicologie, Fédération de Toxicologie, AH-HP, Hôpital Lariboisière, 2 rue Ambroise Paré, Paris 75010, France; Université Paris-Cité, INSERM, Optimisation thérapeutique en neuropharmacologie INSERM UMRS, 1144, 4 avenue de l'Observatoire, Paris 75006, France.

Forensic Science International
|June 2, 2026
PubMed
Summary
This summary is machine-generated.

Volumetric absorptive microsampling (VAMS) provides reliable qualitative toxicological screening in forensic autopsies. This method effectively identifies new psychoactive substances and metabolites, even with limited sample volumes.

Keywords:
Forensic toxicologyHigh resolution mass spectrometryMitra™ deviceToxicological screeningVolumetric absorptive microsampling (VAMS)

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Area of Science:

  • Forensic toxicology
  • Analytical chemistry
  • Pharmacology

Background:

  • Volumetric absorptive microsampling (VAMS) is an emerging technique for toxicological analysis.
  • Its utility in forensic autopsy settings requires further documentation.
  • New psychoactive substances (NPS) pose challenges in post-mortem investigations.

Purpose of the Study:

  • To evaluate Mitra™ VAMS devices for qualitative toxicological screening in a medico-legal autopsy.
  • To assess VAMS applicability for identifying new psychoactive substances (NPS) and their metabolites.
  • To compare VAMS performance against conventional sampling methods.

Main Methods:

  • Autopsy samples (blood, urine, bile, vitreous humor) collected using conventional and Mitra™ VAMS devices.
  • Analysis via liquid chromatography-high-resolution mass spectrometry (LC-HRMS).
  • Employing both targeted and untargeted screening approaches, including molecular networking.

Main Results:

  • Comparable qualitative detection profiles between conventional and VAMS samples across all matrices.
  • Identification of methamphetamine, opioids, and the synthetic cathinone α-PHP using targeted screening.
  • Characterization of α-PHP and its metabolites via untargeted analysis and molecular networking, establishing a metabolic profile.

Conclusions:

  • Mitra™ VAMS devices are suitable for qualitative toxicological screening and non-targeted analysis in post-mortem investigations, especially when sample volume is limited.
  • Integrating VAMS into a structured workflow combining targeted and non-targeted HRMS enhances forensic toxicological analysis.
  • VAMS shows potential for improving forensic identification strategies in challenging cases.