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Shape-Conserving Atom Replacements

Mikus Puriņš1, Cecile Elgindy1, Mark D Levin1

  • 1Department of Chemistry, University of Chicago, Chicago, Illinois 60637, United States.

Chemical Reviews
|June 2, 2026
PubMed
Summary

Skeletal editing reactions enable atom replacement in molecules, accelerating molecular optimization for drug discovery. This review categorizes these reactions and discusses strategies for shape-conserving transformations.

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