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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
Reproductive Cloning01:27

Reproductive Cloning

Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic cell—any cell that is not a sex...

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Related Experiment Video

Updated: Jun 4, 2026

Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model
07:02

Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model

Published on: May 16, 2019

Recurrent assisted reproductive technology failure: the embryo perspective.

Paul Pirtea1, Richard T Scott2, Jason Franasiak3

  • 1Department of Obstetrics, Gynecology and Reproductive Medicine, Hospital Foch, Suresnes, France.

Fertility and Sterility
|June 2, 2026
PubMed
Summary
This summary is machine-generated.

Embryologic markers can help select embryos during assisted reproductive technology (ART) cycles. However, they have limitations in predicting future reproductive success after recurrent ART failure.

Keywords:
ART failureembryo developmentembryo diagnosticsembryo metabolomics

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Last Updated: Jun 4, 2026

Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model
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Measurement of Four Uterine NK Cell Subtypes Using Multiplexed Fluorescent Immunohistochemical Staining in Women with Repeated Implantation Failure
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Measurement of Four Uterine NK Cell Subtypes Using Multiplexed Fluorescent Immunohistochemical Staining in Women with Repeated Implantation Failure

Published on: October 25, 2024

Area of Science:

  • Reproductive Medicine
  • Embryology
  • Clinical Genetics

Background:

  • Recurrent assisted reproductive technology (ART) failure necessitates improved prediction methods beyond traditional embryo morphology.
  • Identifying reliable embryologic markers is crucial for understanding implantation failures.

Purpose of the Study:

  • To evaluate the utility of embryologic markers in predicting outcomes after recurrent ART failure.
  • To assess the limitations of current embryologic markers in forecasting reproductive potential.

Main Methods:

  • Review of current evidence on embryologic markers and their association with ART success.
  • Analysis of specific embryologic phenotypes and their etiological implications.

Main Results:

  • Most embryologic abnormalities in limited cycles do not justify deterministic counseling.
  • Exceptional cases like meiotic arrest or cleavage arrest may suggest monogenic causes.
  • Embryologic findings are often multifactorial and probabilistic, not fixed predictors.

Conclusions:

  • Clinicians must be cautious about overinterpreting embryologic findings as definitive predictors.
  • Embryologic markers should inform intra-cycle embryo selection but have limitations for long-term prognosis.
  • Recurrent ART failure is complex and rarely explained by a single embryologic metric.