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Viral Recombination00:57

Viral Recombination

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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

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Updated: Jun 4, 2026

Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 2
10:55

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Published on: April 10, 2009

Temporal Association Between Viral Infections and Intussusception: Comparing SARS-CoV-2 and Adenovirus Using

Daisuke Miyamori1, Masanori Ito1

  • 1Department of General Internal Medicine, Hiroshima University Hospital, Hiroshima-shi, Hiroshima, Japan.

The Journal of Pediatrics
|June 2, 2026
PubMed
Summary
This summary is machine-generated.

Both SARS-CoV-2 and adenovirus infections increase the risk of pediatric intussusception in children. Adenovirus infections showed a stronger association with this gastrointestinal condition.

Keywords:
SARS-CoV-2adenovirusclaims databaserisk intervalconditional logistic regressionintussusceptionnested case-controlself-controlled risk interval

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Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 2
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Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 1
12:00

Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 1

Published on: April 8, 2009

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Epidemiology

Background:

  • Intussusception is a serious gastrointestinal emergency in children.
  • The role of viral infections, including SARS-CoV-2 and adenovirus, in pediatric intussusception requires further investigation.

Purpose of the Study:

  • To assess the short-term risk of intussusception following SARS-CoV-2 and adenovirus infections in pediatric populations.
  • To quantify the association between these viral infections and intussusception using robust epidemiological methods.

Main Methods:

  • A self-controlled risk interval (SCRI) design and a nested case-control (NCC) analysis were utilized.
  • Japan's national health insurance claims database (2015-2022) was analyzed for children under 10 years old.
  • Conditional logistic regression and Monte Carlo resampling ensured robust statistical analysis and validity.

Main Results:

  • A 4-fold increased incidence of intussusception was observed within 1 month of SARS-CoV-2 infection (IRR 4.27).
  • A 6-fold increased incidence of intussusception was linked to adenovirus infection (IRR 6.09).
  • NCC analysis confirmed these findings, with higher odds for adenovirus (OR 8.21) compared to SARS-CoV-2 (OR 4.43).

Conclusions:

  • Population-scale evidence indicates that both SARS-CoV-2 and adenovirus infections are associated with pediatric intussusception.
  • Adenovirus infection presents a stronger risk factor for intussusception than SARS-CoV-2 infection.
  • Findings emphasize the need for clinical vigilance regarding viral infections and gastrointestinal complications in children.