Related Experiment Video
Updated: Jun 4, 2026

Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 2
Published on: April 10, 2009
Temporal Association Between Viral Infections and Intussusception: Comparing SARS-CoV-2 and Adenovirus Using
Daisuke Miyamori1, Masanori Ito1
1Department of General Internal Medicine, Hiroshima University Hospital, Hiroshima-shi, Hiroshima, Japan.
Objective:
To investigate the short-term risk of intussusception following SARS-CoV-2 and adenovirus infections in children.
Study Design:
Using Japan's health insurance claims database from January 2015 to December 2022, a self-controlled risk interval design and a nested case-control analysis with conditional logistic regression were employed to adjust for individual confounders and assess the robustness of the findings.
Results:
The study included 3.6 million children aged <10 years, with 1069 intussusception events identified by procedure codes. The self-controlled risk interval analysis revealed a 4-fold increased incidence of intussusception within 0-1 months of SARS-CoV-2 infection (incidence rate ratio 4.27, 95% CI 2.11-8.67) and a 6-fold increased incidence for adenovirus infection (incidence rate ratio 6.09, 95% CI 3.18-11.66). The nested case-control analysis yielded consistent results, with odds ratios of 4.43 (95% CI 2.94-6.66) for SARS-CoV-2 and 8.21 (95% CI 6.12-11.02) for adenovirus. Monte Carlo resampling confirmed the stability of the estimates. Negative control windows showed no increased risk, supporting the validity of the observed associations.
Conclusions:
This study provides population-scale evidence that both SARS-CoV-2 and adenovirus infections are associated with the risk of pediatric intussusception, with adenovirus demonstrating a stronger effect. The findings have implications for clinical vigilance and understanding the impact of viral infections on gastrointestinal disorders in children.
Related Concept Videos
Viral Recombination
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Poliomyelitis
Respiratory Syncytial Virus Disease
Single Nucleotide Polymorphisms-SNPs

