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Updated: Jun 4, 2026
09:59
A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
Published on: September 16, 2017
Early time to first recurrence predicts multiple recurrent ischemic strokes: A 2.5-year prospective cohort study
Zhuoyi Wang1, Juehua Zhu2, Shuanggen Zhu3
1Department of Neurology, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 299 Qingyang Road, Wuxi 214023, China.
Neuroscience
|June 2, 2026
Summary
Identifying patients at high risk for recurrent ischemic stroke is key for prevention. An early first stroke recurrence, especially within 6.65 months, predicts multiple future events, requiring intensified secondary prevention.
Area of Science:
- Neurology
- Cardiovascular Research
- Public Health
Background:
- Ischemic stroke recurrence poses a significant health risk.
- Identifying high-risk individuals for multiple strokes is crucial for effective secondary prevention.
Purpose of the Study:
- To identify predictors of multiple ischemic stroke recurrences.
- To determine the optimal time-to-first-recurrence threshold for identifying high-risk patients.
Main Methods:
- Prospective cohort study of 5,040 first-ever ischemic stroke patients.
- Follow-up for 2.5 years, documenting recurrent ischemic stroke events and medication adherence.
- Statistical analysis including multivariable logistic regression and ROC analysis.
Main Results:
- 8.43% of patients experienced at least one recurrence; 1.19% had multiple recurrences.
- A shorter time to first recurrence was significantly associated with multiple recurrences (P=0.008).
- A time-to-first-recurrence threshold of 6.65 months predicted subsequent multiple strokes (OR=0.704, P=0.012).
Conclusions:
- One in seven patients with recurrent stroke experienced multiple events.
- Early first recurrence (within 6.65 months) is a strong predictor of multiple recurrences.
- Patients with early first recurrence require prioritized and intensified secondary prevention strategies.
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