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Updated: Jun 4, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
Published on: April 10, 2026
Cathelicidin antimicrobial peptides: current progress and future prospects in immunotherapy
Aibo Ding1, Zhonghua Lu2, Jiajing Wu3
1The First Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, China; School of Life Sciences, Anhui Medical University, Hefei, Anhui, 230032, China.
Abstract:
Antimicrobial peptides (AMPs) are small molecules with defensive effects that are crucial in innate immune defense. Cathelicidin AMPs are a major AMP family found in humans and other vertebrates, originating from various cell types such as neutrophils, macrophages, pancreatic β-cells and epithelial cells. Cathelicidin AMPs serve as a vital line of defense for the immune system. With the rise of antibiotic resistance, many studies are paying attention to cathelicidin AMPs, classic distinctive small immunopeptides. This article provides a systematic review of the molecular structure, biological role and mechanism of cathelicidin AMPs, along with its advancement in clinical application for treating both infectious and non-infectious disease. Additionally, this review points out the future research direction and potential application of cathelicidin AMPs, considering the limitation of current study.
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