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Post-COVID-19 Leucine-Rich Glioma Inactivated 1 Autoimmune Limbic Encephalitis in an Aviator
Aerospace Medicine and Human Performance
|June 2, 2026
Summary
A commercial pilot developed leucine-rich glioma inactivated 1 (LGI-1) autoimmune limbic encephalitis after COVID-19. This rare neurological condition, confirmed by positive anti-LGI-1 antibodies, rendered him medically unfit for aviation duties.
Area of Science:
- Neurology
- Aviation Medicine
- Infectious Disease Immunology
Background:
- Autoimmune limbic encephalitis is a rare neurological disorder.
- Post-COVID-19 autoimmune limbic encephalitis is exceptionally rare, with few reported cases.
- Previous cases lacked anti-leucine-rich glioma inactivated 1 antibody (LGI-1) positivity, except for two reports.
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