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Updated: Jun 4, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
Published on: August 4, 2023
Treatment of Coagulopathy
Nicole Keefe1, Rain Miller2, Kevin Wang1
1Vascular and Interventional Radiology, University of North Carolina, Chapel Hill, NC.
Vascular and interventional radiology physicians must manage patient bleeding risks by understanding coagulopathies. This involves knowing anticoagulants, critical care coagulopathies, and blood products for safer procedures.
Area of Science:
- Medicine
- Radiology
- Critical Care
Background:
- Bleeding is a significant risk in vascular and interventional radiology (VIR) procedures.
- Coagulopathic abnormalities are prevalent in critically ill patients requiring emergent VIR interventions.
Purpose of the Study:
- To enhance VIR physicians' clinical understanding of coagulopathies.
- To guide VIR physicians in providing recommendations for managing common coagulopathies.
Main Methods:
- Review of common anticoagulants, antithrombotic agents, and their reversal agents.
- Evaluation and management strategies for critical care coagulopathies (DIC, HIT, uremic platelet dysfunction, liver disease-related).
- Discussion on the role of blood product transfusions and management in low vs. high bleeding risk VIR procedures.
Main Results:
- Provides a comprehensive overview of coagulopathy management relevant to VIR.
- Highlights the importance of VIR physicians acting as clinicians in managing patient hemostasis.
- Offers guidance for timely VIR interventions in critically ill patients with coagulopathies.
Conclusions:
- Understanding and managing coagulopathies is crucial for VIR physicians.
- Effective management ensures timely and safe VIR interventions for critically ill patients.
- Empowers VIR physicians to guide primary teams in correcting hemostatic abnormalities.
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