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Published on: May 16, 2025
Cognitive impairment in patients with rheumatoid arthritis in relation to disease activity: A cross-sectional
Marco Tobar-Marcillo1, Diana Camila Fernández Delgado2, Nathalia Sofía Eraso Muñoz2
1Programa de Medicina, Universidad de Nariño, San Juan de Pasto, Nariño, Colombia; Servicio de Reumatología, Hospital Universitario Departamental de Nariño, San Juan de Pasto, Nariño, Colombia.
Introduction:
Rheumatoid arthritis (RA) is an immune-mediated disease that affects multiple organs. Among its extra-articular manifestations is cognitive impairment (CI).
Methodology:
This was an observational, cross-sectional study with an analytical approach, including 59 patients with RA from three specialized outpatient centers in the city of Pasto, Colombia. Data were collected on disease activity using the DAS28 scale, as well as the degree of CI using the Montreal Cognitive Assessment (MoCA).
Results:
A total of 44.1% of participants were classified as having suspected CI, with lower performance across all assessed subdomains. The most affected domains were visuospatial abilities and language. In the multivariate model, lower educational level was associated with CI, while age, glucocorticoid use, disease activity, and functional disability did not show an independent association.
Conclusion:
CI has a higher prevalence in patients with RA compared with the general population, with no relationship found between CI and disease activity.
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