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Neuronal size and geometry shape brain function
1University of Chinese Academy of Sciences, Beijing 100101, China; Laboratory of Integrative Physiology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Abstract:
Neuronal size varies across evolution, diseases, and brain regions. It has long been regarded as a descriptor, not a driver of function. Using triploid Xenopus, Liu et al. show that neuronal enlargement remodels neurite geometry, reduces proliferation, increases phospho-extracellular signal regulated kinase (pERK) responses, and alters behavior, linking cellular scaling to brain function.
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