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Updated: Jun 4, 2026
Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice
Published on: July 11, 2025
Changes in the Expression Levels of Hypoxia-Inducible Factor Isoforms and Their Regulating microRNAs in Peripheral
M V Kirillova1, D Sh Dzhalilova2, O V Makarova2
1Petrovsky National Research Center of Surgery, Avtsyn Research Institute of Human Morphology, Moscow, Russia. marusyasilina99@yandex.ru.
Abstract:
Following a single, severe hypoxic exposure (7000 m, 1 h), changes in the expression levels of Hif1a, Epas1 (Hif2a), and Hif3a mRNA, as well as miR-210, miR-107, miR-145, and miR-155 microRNAs in peripheral blood leukocytes were assessed in hypoxia-tolerant (HT) and hypoxia-susceptible (HS) male Wistar rats. HT animals exhibited a significant 148% increase in Epas1 expression, and HS animals demonstrated a 142% increase in Hif3a expression. Reduced expression levels of rno-miR-210-3p, rno-miR-145-3p, and rno-miR-155-3p in HT rats and increased expression of rno-miR-107-5p in HS rats were also detected. These differences confirm previous data obtained in in vitro and in vivo experiments and indicate a more pronounced adaptive response to oxygen deficiency in HS animals.
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