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  3. Dynamic Cell Fate Transitions During Morphallactic Regeneration.
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  3. Dynamic Cell Fate Transitions During Morphallactic Regeneration.

Related Experiment Video

Methods for the Study of Regeneration in Stentor
08:48

Methods for the Study of Regeneration in Stentor

Published on: June 13, 2018

Dynamic cell fate transitions during morphallactic regeneration.

Clara Nuninger1,2, Panagiotis Papasaikas1,3, Sera L Weevers1,2

  • 1Friedrich Miescher Institute for Biomedical Research, Fabrikstrasse 24, Basel, Switzerland.

Nature Communications
|June 2, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Morphallactic regeneration in Hydra involves a temporal cell identity sequence, with proximal structures appearing before distal ones. This study reveals dynamic Wnt signaling crucial for re-establishing body patterning during regeneration.

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Area of Science:

  • Developmental Biology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Epimorphic regeneration mechanisms are well-studied.
  • Morphallactic regeneration, involving tissue remodeling, has less understood spatiotemporal dynamics.

Purpose of the Study:

  • To elucidate the spatiotemporal dynamics of morphallactic regeneration in Hydra.
  • To investigate cell identity transitions and signaling activity during regeneration.

Main Methods:

  • Time-course single-cell RNA sequencing (scRNA-seq) of regenerating Hydra tissue.
  • Analysis of transcriptional signatures and Wnt signaling dynamics.

Main Results:

  • Morphallaxis shows a temporal sequence of cell identity re-emergence, with proximal signatures preceding distal ones.
  • Wnt signaling remains dynamically active and changes composition over time at the amputation site.

    • Conclusions:

    • Provides a high-resolution view of cell state transitions and signaling in morphallactic regeneration.
    • Offers a framework for understanding organizer function and axial patterning re-establishment in Hydra.