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Related Concept Videos

Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...
Morphogenesis02:19

Morphogenesis

Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cellular Differentiation00:57

Cellular Differentiation

How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...

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Related Experiment Video

Updated: Jun 4, 2026

Methods for the Study of Regeneration in Stentor
08:48

Methods for the Study of Regeneration in Stentor

Published on: June 13, 2018

Dynamic cell fate transitions during morphallactic regeneration.

Clara Nuninger1,2, Panagiotis Papasaikas1,3, Sera L Weevers1,2

  • 1Friedrich Miescher Institute for Biomedical Research, Fabrikstrasse 24, Basel, Switzerland.

Nature Communications
|June 2, 2026
PubMed
Summary
This summary is machine-generated.

Morphallactic regeneration in Hydra involves a temporal cell identity sequence, with proximal structures appearing before distal ones. This study reveals dynamic Wnt signaling crucial for re-establishing body patterning during regeneration.

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Last Updated: Jun 4, 2026

Methods for the Study of Regeneration in Stentor
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Published on: June 13, 2018

Chemical Amputation and Regeneration of the Pharynx in the Planarian Schmidtea mediterranea
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Published on: March 26, 2018

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Published on: August 3, 2022

Area of Science:

  • Developmental Biology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Epimorphic regeneration mechanisms are well-studied.
  • Morphallactic regeneration, involving tissue remodeling, has less understood spatiotemporal dynamics.

Purpose of the Study:

  • To elucidate the spatiotemporal dynamics of morphallactic regeneration in Hydra.
  • To investigate cell identity transitions and signaling activity during regeneration.

Main Methods:

  • Time-course single-cell RNA sequencing (scRNA-seq) of regenerating Hydra tissue.
  • Analysis of transcriptional signatures and Wnt signaling dynamics.

Main Results:

  • Morphallaxis shows a temporal sequence of cell identity re-emergence, with proximal signatures preceding distal ones.
  • Wnt signaling remains dynamically active and changes composition over time at the amputation site.

Conclusions:

  • Provides a high-resolution view of cell state transitions and signaling in morphallactic regeneration.
  • Offers a framework for understanding organizer function and axial patterning re-establishment in Hydra.