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Cephapirin concentrations in prostatic and seminal vesicle tissues.
International Journal of Clinical Pharmacology and Biopharmacy
|February 1, 1979
Summary
Preoperative intravenous infusion of sodium cephapirin achieved bactericidal drug levels in prostate and seminal vesicle tissues. This antibiotic prophylaxis is effective for patients undergoing prostatectomy, targeting potential infections.
Area of Science:
- Pharmacology
- Urology
- Infectious Disease
Background:
- Prostatectomy is a common surgical procedure.
- Bacterial prostatitis can complicate recovery.
- Effective antibiotic prophylaxis is crucial for surgical site infection prevention.
Purpose of the Study:
- To determine cephapirin concentrations in prostate and seminal vesicle tissues.
- To evaluate the efficacy of sodium cephapirin as a preoperative antibiotic for prostatectomy.
Main Methods:
- Administered 1g or 2g of sodium cephapirin intravenously over 15 minutes preoperatively.
- Collected blood and tissue samples (prostate, seminal vesicle) 30 minutes post-infusion.
- Measured cephapirin levels using pharmacokinetic analysis.
Main Results:
- Blood cephapirin levels averaged 25.9 µg/ml (1g dose) and 47.5 µg/ml (2g dose).
- Prostatic tissue levels averaged 24.5 µg/g (1g) and 25.8 µg/g (2g).
- Seminal vesicle levels averaged 12.5 µg/g (1g) and 44.8 µg/g (2g).
Conclusions:
- Sodium cephapirin achieves bactericidal concentrations in prostate and seminal vesicle tissues.
- The 2g dose demonstrated higher levels in seminal vesicles.
- Cephapirin is a suitable prophylactic agent for prostatectomy patients.