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Characterizing Lewis Pairs Using Titration Coupled with In Situ Infrared Spectroscopy
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Unlocking Lewis acid-free metalation of O-nucleophiles in HFIP
Kacper Łyczek1, Martyna Markwitz1, Maciej Janicki2
1Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznanskiego 8, 61-614, Poznan, Poland.
Abstract:
Allylsilanes are primarily used in allylation reactions that form new C-C bonds. Although they can also serve as silylating reagents to generate Si-O bonds, such transformations have generally required Brønsted or Lewis acid catalysis. Herein, we describe an acid-free method to access silyl ethers, siloxanes, and borasiloxanes via silylation or borylation. Hexafluoroisopropanol enables this reactivity, allowing a wide range of alcohols and silanols to undergo efficient conversion under mild conditions.
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