Related Experiment Video

Updated: Jun 4, 2026

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
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Published on: September 29, 2011

DREAM repressive activity links somatic mutation, lifespan and disease

Zane Koch1, Shuvro P Nandi2,3, Kate Licon3

  • 1Program in Bioinformatics and Systems Biology, University of California, San Diego, La Jolla, CA, USA.

Nature Aging
|June 2, 2026
PubMed
Summary

The DREAM complex regulates DNA repair and impacts aging. Lower DREAM activity reduces mutation rates, extends lifespan in mammals, and may protect against Alzheimer's disease.

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