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Updated: Jun 4, 2026

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
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Published on: February 3, 2015

The Present and Future of THERANOSTICS

Winnie Wing-Chuen Lam1,2, Sue Ping Thang1,2, Kelvin Siu-Hoong Loke1,2

  • 1Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore, Singapore.

Asia-Pacific Journal of Clinical Oncology
|June 2, 2026
PubMed

Insights

Radiotheranostics, combining cancer detection and treatment, are advancing precision medicine. This review covers approved and investigational radiopharmaceuticals, new targets, and challenges, particularly in Asia.

Area of Science:

  • Nuclear medicine
  • Oncology
  • Radiopharmaceutical therapy

Background:

  • Growing global interest in radiotheranostics for precision cancer medicine.
  • Radiotheranostics offer targeted detection and treatment of cancer.

Purpose of the Study:

  • Review current developments in radiopharmaceutical therapy.
  • Discuss approved agents, late-stage clinical trials, and emerging radionuclides/targets.
  • Examine operational, regulatory, and regional challenges, including in East and Southeast Asia.

Main Methods:

  • Literature review of radiopharmaceutical developments.
  • Analysis of approved radiopharmaceuticals and agents in clinical trials.
  • Discussion of novel ligands, targets, and therapeutic combinations.

Main Results:

  • Overview of approved radiopharmaceuticals and those in late-stage trials.
  • Identification of emerging radionuclides and cancer targets.
  • Exploration of challenges in radiopharmaceutical therapy implementation.

Conclusions:

  • Radiotheranostics represent a significant advancement in precision oncology.
  • Continued research and development are crucial for expanding radiopharmaceutical applications.
  • Addressing regulatory and operational hurdles is key for wider adoption, especially in diverse Asian healthcare systems.
Keywords:
oncologyradiopharmaceuticalstargeted radioligand therapytheranostics

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