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Updated: Jun 4, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
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Electrochemical Thiocyanation Utilizing Ammonium Carbamodithioate or NH3·H2O and CS2: A Protocol for Synthesizing

Zan Chen1, Jun-Fa Pang1,2, Shirui Wu1

  • 1College of Chemistry and Civil Engineering, Shaoguan University, Shaoguan 512005, P. R. China.

The Journal of Organic Chemistry
|June 3, 2026
PubMed

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One of the common methods to prepare nitriles is the dehydration of amides. This method requires strong dehydrating agents like phosphorous pentoxide or boiling acetic anhydride for converting amides to nitriles. Another reagent namely, thionyl chloride also accomplishes the dehydration of amides, where amide acts as a nucleophile. The first step of the mechanism involves the nucleophilic attack by the amide on the thionyl chloride to form an intermediate. In the next step, the electron pairs...
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