Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Malaria

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

Symbiosis

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hepatitis B virus prevalence, susceptibility and care engagement among vulnerable migrant populations in Rome.

BMC infectious diseases·2026

Same author

Hepatic Alpha-1 Antitrypsin Globules in Compound Heterozygous SERPINA1 Variants Previously Considered Non-Polymerizing: A Case Report.

International journal of molecular sciences·2026

Same author

Ecotourism and the Hidden Ecology of Infection: The Andes Virus Cruise Outbreak.

Infectious disease reports·2026

Same author

Assessing the burden of diabetes mellitus in dengue patients: A systematic review and meta-analysis.

New microbes and new infections·2026

Same author

AdMiRE study: Development and validation of a WHO-aligned tool to assess healthcare access and antibiotic use among migrant populations in Europe-a multicountry Delphi and psychometric study on behalf of ESGITM group.

CMI communications·2026

Same author

Clinical challenges and delayed diagnosis of Lyme borreliosis in non-endemic regions: A case series.

Travel medicine and infectious disease·2026

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

Published on: June 8, 2017

Malignant malaria: autopsy findings and morphological features.

Daniele Colombo¹, Franca Del Nonno², Alessandra D'Abramo³

¹Department of Pathology, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Via Portuense 292, 00149, Rome, Italy.

Malaria Journal

|June 3, 2026

Summary

Autopsy revealed cerebral malaria as the cause of death in a traveler from Central Africa. This case emphasizes the importance of considering Plasmodium falciparum in febrile travelers.

Keywords:

Plasmodium falciparum Autopsy Brain lesions Disseminated intravascular coagulation Imported malaria Severe malaria

More Related Videos

Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice

Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice

Published on: January 2, 2013

Preparing Lamellae from Vitreous Biological Samples Using a Dual-Beam Scanning Electron Microscope for Cryo-Electron Tomography

Preparing Lamellae from Vitreous Biological Samples Using a Dual-Beam Scanning Electron Microscope for Cryo-Electron Tomography

Published on: August 5, 2021

Related Experiment Videos

Last Updated: Jun 4, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

Published on: June 8, 2017

Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice

Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice

Published on: January 2, 2013

Preparing Lamellae from Vitreous Biological Samples Using a Dual-Beam Scanning Electron Microscope for Cryo-Electron Tomography

Preparing Lamellae from Vitreous Biological Samples Using a Dual-Beam Scanning Electron Microscope for Cryo-Electron Tomography

Published on: August 5, 2021

Area of Science:

Pathology
Infectious Diseases
Tropical Medicine

Background:

Malignant malaria caused by Plasmodium falciparum is a major cause of mortality in sub-Saharan Africa.
Plasmodium falciparum infection leads to red blood cell aggregation, microvascular obstruction, ischemia, and hemorrhages.
Autopsy is crucial for diagnosing the cause of death in sudden malaria cases.

Purpose of the Study:

To report a case of fatal cerebral malaria with detailed autopsy findings.
To determine the cause of death and contributing factors in a severe malaria case.
To highlight the diagnostic importance of autopsy in malaria.

Main Methods:

A case report of a 54-year-old woman with untreated multiple myeloma who traveled to Central Africa without chemoprophylaxis.
The patient presented with fever, headache, and asthenia, rapidly progressing to multiorgan failure and death.
Autopsy was performed to ascertain the cause of death.

Main Results:

The autopsy identified cerebral malaria as the cause of death.
The findings illustrated the pathological consequences of Plasmodium falciparum infection.
The case demonstrated the rapid progression to fatal outcomes in severe malaria.

Conclusions:

Plasmodium falciparum infection can be fatal, necessitating accurate diagnosis.
Autopsy findings are vital for confirming the role of malaria in mortality.
Clinicians should consider Plasmodium falciparum in febrile travelers from endemic areas.