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A Universal Tag To Supercharge Proteins for Cytosolic Delivery

Yanan Quan1, Weina Jing1, Lei Peng1

  • 1Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, Hubei, China.

Molecular Pharmaceutics
|June 3, 2026
PubMed
Summary

Researchers developed a novel tagging strategy to create supercharged proteins for enhanced cellular delivery. This method, using a CBB-bearing peptide, efficiently delivers functional proteins to the cytosol without mutagenesis, outperforming existing techniques.

Keywords:
CBBcytosolic deliveryintracellular targetssupercharged proteintagging

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