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IL-27: A Double-Edged Sword in Immune Regulation via JAK-STAT Orchestration

Xiangqi Zhang1,2,3, Chen Feng2,3, Ye Xu4

  • 1Department of Immunology, School of Basic Medical Science, Central South University, Changsha, Hunan, China, csu.edu.cn.

Journal of Immunology Research
|June 3, 2026
PubMed
Summary

Interleukin-27 (IL-27) is a complex cytokine with dual roles in immunity, acting as both pro-inflammatory and immunosuppressive. Understanding its Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway signaling is key for targeted immunotherapies.

Keywords:
IL-27immune regulationinflammationthe JAK-STAT signaling pathway

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