Related Experiment Video

Updated: Jun 4, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

Life satisfaction mediates advanced maternal age at childbirth and frailty across cohorts

Zheng-Hui Zhao1, Wenze Tian2, Xiaoyu Wang3

  • 1Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, China.

Iscience
|June 3, 2026
PubMed

Advanced maternal age at childbirth (AMAC) is increasingly common, yet its long-term association with frailty remains unclear. Using three longitudinal cohorts (CHARLS, KLoSA, and HRS; N = 21,090), we examined this association via Cox proportional hazards models and mediation analysis. After multivariable adjustment, AMAC (≥35 years) was associated with increased frailty risk in the Chinese (hazard ratio [HR]: 1.21, 95% confidence interval [CI]: 1.03-1.42) and Korean (HR: 1.24, 95% CI: 1.02-1.50) cohorts, while AMAC (≥40 years) showed a similar direction in the United States cohort. Life satisfaction partially mediated this association, accounting for 8.9% of the total effect in KLoSA and 22.4% in HRS, with substantial attenuation of the direct effect in CHARLS. These cross-national findings indicate that psychosocial well-being may represent a modifiable pathway for frailty prevention among women with a history of AMAC.

Keywords:
Health sciencesInternal medicineLife styleMedicineMental statePatient social contextPregnancyPsychosocial factorPublic healthWomen’s health

More Related Videos

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment04:00

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment

Published on: July 26, 2024

Frailty Assessment in an Aging Mouse Model06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

Related Concept Videos

Erikson's Theory on Socioemotional Development during Adulthood01:27

Erikson's Theory on Socioemotional Development during Adulthood

Erik Erikson's theory of psychosocial development outlines a series of stages through which individuals progress across the lifespan. Each stage involves a psychosocial conflict that significantly influences personal growth and well-being. Three key stages — intimacy versus isolation, generativity versus stagnation, and integrity versus despair — highlight the developmental challenges faced in adulthood.
Intimacy Versus Isolation in Early Adulthood
Individuals in early adulthood, from the 20s...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...