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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Redox Stress Biomarkers and Their Association With Renal Dysfunction in Chronic Kidney Disease
Sri Lakshmi Kothakapa1, Sulekha Ramireddy2, Sanjay Reddy Thanugundla2
1Internal Medicine, Malla Reddy Institute of Medical Sciences, Hyderabad, IND.
Cureus
|June 3, 2026
Summary
Chronic kidney disease (CKD) patients show increased oxidative and nitrosative stress compared to healthy individuals. This imbalance in oxidant production and antioxidant defense may drive CKD progression and complications.
Area of Science:
- Biochemistry
- Nephrology
- Pathophysiology
Background:
- Chronic kidney disease (CKD) is linked to increased oxidative and nitrosative stress.
- Reactive oxygen and nitrogen species contribute to cellular injury and inflammation in CKD.
- This study investigated oxidative and nitrosative stress markers in CKD patients versus healthy controls.
Purpose of the Study:
- To evaluate oxidative and nitrosative stress markers in CKD patients.
- To compare these markers between CKD patients and healthy individuals.
Main Methods:
- A case-control study involving 80 CKD patients and 80 healthy controls.
- Analysis of blood samples for malondialdehyde (MDA), superoxide dismutase (SOD), catalase, and nitric oxide (NO).
- Standard biochemical methods and statistical analysis were employed.
Main Results:
- CKD patients exhibited significantly higher levels of MDA and NO compared to controls (p < 0.001).
- Activity of antioxidant enzymes SOD and catalase was significantly lower in CKD patients (p < 0.001).
- A negative correlation was found between estimated glomerular filtration rate and MDA levels in CKD patients (r = -0.62, p < 0.001).
Conclusions:
- CKD is characterized by a significant imbalance between oxidant production and antioxidant defense.
- Elevated oxidative and nitrosative stress are implicated in CKD progression and complications.
- Monitoring these biomarkers may facilitate early intervention and treatment strategies for oxidative damage.
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