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A New Method for Inducing a Depression-Like Behavior in Rats

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Published on: February 22, 2018

Associations between self-reported depression and functioning across ICF domains: a Danish population-based study.

Pernille Pedersen^1,2, Merjema Zulfikari¹, Marc Sampedro Pilegaard^1,2,3

¹DEFACTUM, Central Denmark Region, Aarhus, Denmark.

Frontiers in Rehabilitation Sciences

|June 3, 2026

Summary

Depression significantly impacts daily functioning, causing widespread disability across physical, social, and psychological domains. This study highlights the International Classification of Functioning, Disability and Health (ICF) framework

Keywords:

Disability and Health (ICF)International Classification of Functioning adults depression disability functioning health survey

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Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Area of Science:

Public Health
Psychiatry
Rehabilitation Medicine

Background:

Depression is a leading cause of disability globally.
Clinical focus has predominantly been on symptom severity, overlooking broader functional impacts.
The International Classification of Functioning, Disability and Health (ICF) provides a framework to assess these broader impacts.

Purpose of the Study:

To investigate the associations between self-reported depression and functioning across all ICF components.
To account for personal and environmental factors influencing depression and functioning.
To evaluate the utility of the ICF framework in understanding the multidimensional nature of depression-related disability.

Main Methods:

Analysis of self-reported data from the 2021 Danish "How are you?" survey.
Utilized logistic regression guided by the ICF framework.
Sample comprised 28,101 adults (aged 25+), with 3,060 (13%) reporting depressive symptoms.

Main Results:

Individuals with self-reported depression experienced significantly more disability across all ICF components compared to those without.
Depression was strongly linked to impairments in body functions (e.g., poor sleep, stress, loneliness) and structures.
Significant activity limitations and participation restrictions were observed, including needing assistance with daily activities, healthcare engagement difficulties, and reduced work/community involvement.

Conclusions:

Self-reported depression is associated with extensive disability spanning psychological, social, and physical areas.
Findings affirm the ICF's value in comprehensively mapping depression's multidimensional impact at a population level.
The results support enhanced assessment and rehabilitation strategies informed by the ICF framework.