Related Experiment Video
Updated: Jun 4, 2026
Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
Published on: September 20, 2024
Atypical language lateralization and contralateral epileptiform activity in a right-handed patient with a left
Ahmed Hafez Mousa1, Badr E Hafiz2, Waseem Th Alharthi3
1Department of Neurosurgery, Dubai Health, Dubai, United Arab Emirates.
Background:
Adult-onset epilepsy due to intracranial focal lesions in one hemisphere mostly results in language function lateralization to the contralateral hemisphere. However, cortical reorganization in certain cases has led to atypical lateralization patterns. In view of this variability, comprehensive presurgical diagnostics and planning have proven to be essential in preventing postoperative complications.
Case Description:
We report a clinically significant case of a right-handed 40-year-old male presenting with new-onset focal epilepsy secondary to a small, nonenhancing expansile lesion in the left middle frontal gyrus. Multimodal presurgical workup revealed atypical right hemisphere language dominance and interictal epileptiform discharges over the contralateral right temporal region, raising unique considerations for surgical planning.
Conclusion:
This case highlights the value of integrated functional magnetic resonance imaging and electroencephalography assessment in epilepsy surgery, especially in the context of cortical reorganization.
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Related Concept Videos
01:28Lateralization
01:05Cerebral Hemispheres
01:10Higher Mental Functions of the Brain: Language
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...