Related Experiment Video
Updated: Jun 4, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
First Description of Nonlupus Full-House Nephropathy in Systemic Juvenile Idiopathic Arthritis Responsive to
Lucas Jacobs1, Valérie Badot2, Carole Nagant3
1Nephrology-Dialysis Department, Brugmann University Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Abstract:
Nonlupus full-house nephropathy (NL-FHN) is a distinct clinicopathological entity defined as the concurrent positive staining for immunoglobulin A, immunoglobulin G, immunoglobulin M, C3, and C1q at immunofluorescence or immunohistochemistry on kidney biopsy samples with lupus nephritis light microscopy lesions without clinical and laboratory features of systemic lupus erythematosus. Secondary forms of NL-FHN are mainly infectious in ∼40% of cases (human immunodeficiency virus and Bartonella being the leading infectious causes). Autoimmune diseases represent less than 20% of secondary NL-FHNs. The renal prognosis is usually poor because NL-FHN has been reported as an independent risk factor for end-stage renal disease in clinical studies. To our knowledge, we report the first case of NL-FHN associated with systemic juvenile idiopathic arthritis. Interestingly, despite the poor prognosis of NL-FHN reported in the literature, we observed a complete renal response after early identification and subsequent tocilizumab regimen tailored by clinical manifestations and disease activity. This observation highlights the importance of early diagnosis and the potential link between underlying autoimmune disease and the development of NL-FHN in some patients.
Related Concept Videos
Nephrotic Syndrome I : Introduction
Nephrotic Syndrome II : Assessment and Medical Management
Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease I: Introduction
Nephrotic Syndrome III : Nursing Management
Acute Kidney Injury III: Clinical Manifestations