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Updated: Jun 4, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
Concomitant Liwen procedure and minimally invasive direct coronary artery bypass via a single access: a
Xinyu Li1,2, Shurui Xie1, Zhengchun Yu1
1Department of Ultrasound, Wuhan Asia Heart Hospital Affiliated to Wuhan University of Science and Technology, Wuhan Clinical Medical Research Center of Cardiovascular Imaging, No. 753 Jinghan Avenue, Wuhan 430022, China.
Background:
Advances in anaesthesia and minimally invasive surgical techniques have expanded therapeutic options for patients with complex cardiac disease. While conventional open-heart surgery carries significant risks for this population, hybrid strategies offer a viable alternative.
Case Summary:
We report the first case of concurrent hypertrophic obstructive cardiomyopathy (HOCM) and coronary artery disease (CAD) treated with a one-stage hybrid strategy: combining the Liwen procedure (echocardiography-guided percutaneous intramyocardial septal radiofrequency ablation) with minimally invasive direct coronary artery bypass (MIDCAB) via a single access. This approach effectively addressed both left ventricular outflow tract obstruction and myocardial ischaemia, while reducing trauma and accelerating recovery.
Discussion:
This case demonstrates that the concomitant Liwen procedure and MIDCAB through a single minimally invasive access is a feasible and promising strategy for patients with coexisting HOCM and CAD, offering reduced trauma and faster recovery compared to traditional approaches.
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