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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Psychoneuroimmunology: Cardiovascular Disease

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Brain Imaging01:14

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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Updated: Jun 4, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Cardiometabolic Risk and Structural Brain Development in a Large Community-Based US Cohort.

Dani Beck1, Lars T Westlye2,3,4, Christian K Tamnes1,5

  • 1PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.

Human Brain Mapping
|June 3, 2026
PubMed
Summary
This summary is machine-generated.

Childhood cardiometabolic health shows limited impact on adolescent brain development. While higher resting heart rate linked to white matter changes, overall brain structure remained largely unaffected by short-term risk factor variations.

Keywords:
MRIbrain developmentcardiometabolicpaediatric

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Public Health

Background:

  • Cardiometabolic risk factors emerge in youth, but their brain development impact is unclear.
  • Understanding this relationship is crucial for early intervention strategies.

Purpose of the Study:

  • To investigate associations between cardiometabolic health and brain structure/microstructure in adolescents.
  • To determine if cardiometabolic changes predict subsequent brain development.

Main Methods:

  • Utilized Adolescent Brain Cognitive Development (ABCD) Study data (N=3527).
  • Analyzed anthropometric, cardiovascular, and metabolic indices against brain metrics (cortical thickness, surface area, white matter integrity).
  • Employed Bayesian multilevel models and sensitivity analyses.

Main Results:

  • Higher resting heart rate correlated with increased white matter mean diffusivity, strengthening over time.
  • Increased waist circumference associated with larger cortical surface area.
  • Most cardiometabolic measures showed no significant association; brain development was largely insensitive to short-term variations.

Conclusions:

  • Brain architecture in late childhood/adolescence appears robust to short-term cardiometabolic risk factor fluctuations.
  • Specific factors like heart rate and waist circumference show nuanced associations with brain development.