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Updated: Jun 4, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Arterial stiffness and choroidal vascularity index in autosomal dominant polycystic kidney disease with preserved

Mehmet Mert, Seher Yılmaz, Nail Işıklı

    Clinical Nephrology
    |June 3, 2026
    PubMed

    Insights

    Autosomal dominant polycystic kidney disease (ADPKD) is linked to increased arterial stiffness and choroidal vascular changes, even in early stages. These findings suggest widespread vascular issues in ADPKD patients with preserved kidney function.

    Area of Science:

    • Vascular Biology
    • Nephrology
    • Ophthalmology

    Background:

    • Autosomal dominant polycystic kidney disease (ADPKD) is a systemic disorder with early vascular effects.
    • Subclinical vascular changes, including arterial stiffness and ocular microvascular alterations, may precede kidney function decline in ADPKD.
    • Limited data exist on the relationship between systemic arterial stiffness and choroidal microvasculature in early ADPKD.

    Purpose of the Study:

    • To investigate the association between systemic arterial stiffness and choroidal microvascular structure in patients with early-stage ADPKD.
    • To compare arterial stiffness and choroidal parameters between ADPKD patients and healthy controls.
    • To identify determinants of arterial stiffness and choroidal vascularity in ADPKD.

    Main Methods:

    • Cross-sectional study including 41 ADPKD patients with preserved kidney function and 40 controls.
    • Arterial stiffness assessed by cardio-ankle vascular index (CAVI).
    • Choroidal microvasculature measured by spectral-domain optical coherence tomography, including choroidal vascularity index (CVI).

    Main Results:

    • ADPKD patients showed significantly higher CAVI and CVI compared to controls.
    • No significant correlation was found between CAVI and CVI.
    • ADPKD status was independently associated with higher CAVI and CVI.

    Conclusions:

    • Early-stage ADPKD is characterized by increased systemic arterial stiffness and choroidal microvascular remodeling.
    • Elevated CAVI and CVI indicate early, multi-level vascular involvement in ADPKD.
    • Combined assessment of systemic and ocular vascular parameters may offer insights into subclinical vascular changes in ADPKD.
    Abstract

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