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Related Experiment Video

Updated: Jun 4, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
05:23

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

Fibrin-Based Scaffold Augmentation During Meniscal Repair May Enhance Healing and Functional Outcomes: A Systematic

Khaled Skaik1, Harjind Kahlon2, Marc Daniel Bouchard3

  • 1Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.

The American Journal of Sports Medicine
|June 3, 2026
PubMed
Summary

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Fibrin-based scaffolds significantly improve meniscal tear healing and patient outcomes compared to standard repair. This systematic review highlights their potential for enhancing recovery in avascular zones.

Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Biomaterials

Background:

  • Meniscal tears often occur in avascular zones, complicating natural healing.
  • Biologic augmentation, particularly fibrin-based scaffolds, is explored to enhance meniscal repair.
  • Clinical evidence for fibrin augmentation in meniscal repair requires systematic evaluation.

Purpose of the Study:

  • To assess healing rates following fibrin-augmented meniscal repair.
  • To evaluate complication rates associated with fibrin-based scaffolds.
  • To analyze patient-reported outcome scores (IKDC, Lysholm, Tegner) after augmentation.

Main Methods:

  • Systematic review adhering to PRISMA guidelines.
  • Searched PubMed, Embase, and Ovid MEDLINE for relevant studies.
Keywords:
augmentationfibrinmeniscal repairmeniscus

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Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
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Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Published on: January 7, 2019

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Last Updated: Jun 4, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
05:23

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
08:02

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Published on: January 7, 2019

  • Included studies comparing fibrin-based augmentation with non-augmented meniscal repair.

    • Main Results:

    • Fifteen studies (438 patients) met inclusion criteria; 345 received fibrin augmentation.
    • Fibrin clot from peripheral venous blood (FC-PVB) showed 77.5% complete healing.
    • FC-PVB augmentation improved IKDC and Lysholm scores; other methods showed consistent improvements.
    • Fibrin-based augmentation yielded superior outcomes compared to non-augmented repair.

    Conclusions:

    • Fibrin-based augmentation demonstrates high healing rates and low complication rates for meniscal tears.
    • Augmentation with fibrin scaffolds improves clinical outcomes and function compared to non-augmented repair.
    • FC-PVB enhances symptom relief and functional recovery; FC-BMAC improved activity levels.