Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hydrogen Bonds01:04

Hydrogen Bonds

A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...
Hydrogen Bonds00:26

Hydrogen Bonds

Hydrogen BondsHydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.Hydrogen Bonds Control the World!Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are...
Polymer Classification: Stereospecificity01:26

Polymer Classification: Stereospecificity

Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
Polymer Classification: Architecture01:14

Polymer Classification: Architecture

Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
Characteristics and Nomenclature of Homopolymers01:00

Characteristics and Nomenclature of Homopolymers

Polymers that are made up of identical monomer units are called homopolymers. Only one repeating unit is involved in the construction of the homopolymer structure. For example, as depicted in Figure 1, polypropylene is a homopolymer constituted of propylene monomers. Here, the only repeating unit in the polymer chain is propylene.
Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oxidation Behavior of TiCN-HfC-WC Cermet at High Temperature.

Materials (Basel, Switzerland)·2026
Same author

Cloning-based analysis of MHC class II DRB variation and Enterocytozoon bieneusi association in the Amur tiger (Panthera tigris altaica).

Molecular and biochemical parasitology·2026
Same author

Syncope as the Initial Presentation of Takayasu Arteritis in a 57-Year-Old Female: A Case Report and Literature Review.

Clinical case reports·2026
Same author

Enhancing glioma immunotherapy by disrupting RBP-J-mediated NNMT signaling in tumor microenvironment.

Oncogene·2026
Same author

Molecular detection and zoonotic genotyping of Enterocytozoon bieneusi in Siberian tigers (Panthera tigris altaica), Northeast China.

Parasitology research·2026
Same author

Finerenone combined with guideline-directed medical therapy in patients with post-myocardial infarction heart failure: a real-world study.

Frontiers in pharmacology·2026
Same journal

Electrospun Liquid Crystal Elastomers as Stress-Free Thermo- and Photoresponsive Actuators.

ACS applied materials & interfaces·2026
Same journal

Tunable Electrical Transport and Magnetic Anisotropy in Textured SrRuO<sub>3</sub> Films Mediated by Gap Control of Monolayer Ca<sub>2</sub>Nb<sub>3</sub>O<sub>10</sub> Nanosheet Templates.

ACS applied materials & interfaces·2026
Same journal

Label-Free Capacitive Immunosensing of Lactate Dehydrogenase and Interleukin-6 Using a Protein-Passivated Graphene Interface.

ACS applied materials & interfaces·2026
Same journal

Improved Carrier Transport and Enhanced Detection Sensitivity Through Zr<sup>4+</sup> Doping in LiYMo<sub>2</sub>O<sub>8</sub> Single Crystals for X-ray Detectors.

ACS applied materials & interfaces·2026
Same journal

Near-Infrared Light-Driven Microgrooved UCNPs/Azobenzene-LCE Actuators and Substrates for Cardiomyoblast Alignment.

ACS applied materials & interfaces·2026
Same journal

Recent Advances in Superlattice-Based Thermoelectrics.

ACS applied materials & interfaces·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2026

Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface
08:42

Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Published on: July 10, 2017

Smart Hydrogen-Bonded Organic Frameworks: From Design Rules to Applications.

Ziyao Wang1, Jiabao Liu2, Hang Tian3

  • 1State Key Laboratory of Porous Materials for Separation and Conversion, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, College of Smart Materials and Future Energy, Fudan University, Shanghai 200438, China.

ACS Applied Materials & Interfaces
|June 3, 2026
PubMed
Summary
This summary is machine-generated.

Hydrogen-bonded organic frameworks (HOFs) offer adaptive porosity through reversible hydrogen bonds, enabling dynamic transformations for advanced applications. These "smart" HOFs show promise in separations, sensing, optoelectronics, and biomedical therapies.

Keywords:
adaptive porosityhydrogen-bonded organic frameworkssmart adsorptionstimuli-responsive materialsstructural flexibility

More Related Videos

Synthesis and Characterization of Functionalized Metal-organic Frameworks
11:27

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

Synthesis and Characterization of Self-Assembled Metal-Organic Framework Monolayers Using Polymer-Coated Particles
06:48

Synthesis and Characterization of Self-Assembled Metal-Organic Framework Monolayers Using Polymer-Coated Particles

Published on: June 14, 2024

Related Experiment Videos

Last Updated: Jun 4, 2026

Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface
08:42

Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Published on: July 10, 2017

Synthesis and Characterization of Functionalized Metal-organic Frameworks
11:27

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

Synthesis and Characterization of Self-Assembled Metal-Organic Framework Monolayers Using Polymer-Coated Particles
06:48

Synthesis and Characterization of Self-Assembled Metal-Organic Framework Monolayers Using Polymer-Coated Particles

Published on: June 14, 2024

Area of Science:

  • Materials Science
  • Supramolecular Chemistry
  • Nanotechnology

Background:

  • Metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) are crystalline porous materials.
  • Hydrogen-bonded organic frameworks (HOFs) represent a paradigm shift with adaptive porosity.
  • HOFs utilize weak, reversible hydrogen interactions, leading to intrinsic framework flexibility.

Purpose of the Study:

  • To systematically discuss the design principles of smart HOFs.
  • To highlight the translation of HOF flexibility into advanced functionalities.
  • To provide an outlook on future challenges and practical deployment of HOFs.

Main Methods:

  • Review and synthesis of existing research on HOF design and applications.
  • Analysis of flexibility mechanisms in HOFs and their impact on functionality.
  • Exploration of HOF applications in separations, sensing, optoelectronics, and biomedicine.

Main Results:

  • HOFs exhibit reversible transformations like breathing, gate-opening, and layer sliding.
  • Adaptive pore environments in HOFs enable molecular discrimination and self-healing in separations.
  • HOFs facilitate precise sensing through stimuli-induced signal transduction (optical/electrical).
  • Dynamic luminescence and topological switching in HOFs are leveraged for optoelectronics and information security.
  • Stimuli-responsive drug release and biocompatibility are explored for HOF-based biomedical therapies.

Conclusions:

  • Smart HOFs offer unique adaptive properties for diverse applications.
  • Challenges remain in HOF stability, predictability, and processability for practical use.
  • Further research is needed to bridge the gap between HOF design and real-world deployment.