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Updated: Jun 4, 2026

Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model

Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model

Published on: August 4, 2017

Reprogramming the Diabetic Wound Microenvironment by Enzyme Cascade-Driven, ROS-Responsive Microspheres.

Cong Ma¹, Yifan Chen¹, Zihao Zong¹

¹School of Food Science and Engineering, South China University of Technology, 381 Wushan Road, Guangzhou, Guangdong 510640, China.

ACS Biomaterials Science & Engineering

|June 3, 2026

Summary

This summary is machine-generated.

A novel microsphere system effectively treats diabetic wounds by managing glucose, oxygen, and oxidative stress. This approach enhances healing by restoring the wound microenvironment through enzymatic reactions and targeted curcumin delivery.

Keywords:

ROS-responsive microspheres angiogenesis promotion diabetic wound healing enzyme cascade reaction microenvironment regulation

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Area of Science:

Biomaterials Science
Regenerative Medicine
Wound Healing

Background:

Diabetic wounds exhibit delayed healing due to hyperglycemia, oxidative stress, and hypoxia.
The wound microenvironment in diabetes impairs angiogenesis and tissue regeneration.
Current treatments struggle to address the complex dysregulation in diabetic wound healing.

Purpose of the Study:

To develop a multifunctional microsphere system for simultaneous regulation of glucose, oxygen, and oxidative stress in diabetic wounds.
To investigate the therapeutic efficacy of ROS-responsive curcumin nanoparticles integrated with glucose oxidase (GOx) and catalase (CAT) for wound healing.
To restore homeostasis in the diabetic wound microenvironment for accelerated tissue regeneration.

Main Methods:

Fabrication of a multifunctional microsphere system incorporating ROS-responsive curcumin nanoparticles, GOx, and CAT.
Utilizing GOx to reduce glucose and generate hydrogen peroxide (H2O2), followed by CAT-mediated H2O2 decomposition to produce oxygen.
Employing ROS-responsive nanoparticles for on-demand curcumin release in oxidative environments.

Main Results:

The microsphere system effectively reduced glucose levels, generated oxygen, and scavenged ROS.
Enhanced angiogenesis, fibroblast migration, and accelerated wound healing were observed.
Histological analyses confirmed reduced inflammation, increased vascularization, and improved tissue regeneration.

Conclusions:

The developed microsphere system demonstrates a promising strategy for diabetic wound management.
Coordinated enzymatic cascades and ROS-responsive drug delivery restore wound microenvironment homeostasis.
The Cur/Enzyme/Nanoclay@Microsphere formulation showed significant therapeutic benefits.