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Updated: Jun 4, 2026

Guidelines and Experience Using Imaging Biomarker Explorer (IBEX) for Radiomics
Published on: January 8, 2018
Paola Minichetti1, Lorenzo Cereser1,2, Eugenia Versienti2
1Institute of Radiology, University Hospital S. Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy.
The latest version of the Breast Imaging-Reporting and Data System (BI-RADS) updates how radiologists describe and report breast imaging findings across mammography, ultrasound, MRI, and contrast-enhanced mammography to improve consistency and patient care.
Area of Science:
Background:
No prior work had resolved the inconsistencies in reporting across diverse breast imaging modalities before the release of the latest manual. That uncertainty drove the need for a unified framework to guide clinical practice. Prior research has shown that standardized terminology improves diagnostic accuracy and communication among medical teams. However, older guidelines struggled to keep pace with rapid technological advancements in digital breast tomosynthesis and contrast-enhanced imaging. This gap motivated the development of updated criteria to ensure that assessment categories remain relevant in modern settings. Previous iterations often lacked the necessary granularity to describe complex findings consistently across different imaging platforms. Clinicians frequently encountered challenges when attempting to harmonize findings from ultrasound with those observed on magnetic resonance imaging. This evolution of the reporting system addresses these historical limitations to provide a more robust foundation for patient management.
Purpose Of The Study:
The aim of this review is to summarize the principal cross-modality and modality-specific changes introduced in the new manual. This work addresses the need to reflect contemporary practice across mammography, ultrasound, MRI, and contrast-enhanced mammography. The authors seek to clarify the implications of these updates for interpretation and reporting. A major focus involves explaining how the new descriptor terminology enhances multidisciplinary communications. The study investigates the impact of revised assessment categories on clinical decision-making processes. Researchers intend to demonstrate how structured lesion localization and tissue composition assessment improve report quality. The motivation for this analysis is to provide a clear guide for clinicians navigating the transition to the updated framework. By detailing these changes, the authors provide a resource for improving auditability and performance monitoring in breast imaging departments.
Main Methods:
Review Approach framing involves a comprehensive synthesis of the principal cross-modality and modality-specific changes introduced in the new manual. The authors evaluated the updated structured clinical indication categories and revised report organization protocols. This analysis focused on the harmonization of terminology and the refinement of morphologic descriptors across various platforms. The team examined the introduction of subclassification for breast MRI to ensure alignment with other diagnostic tools. The investigation assessed the formal incorporation of contrast-enhanced mammography into the established reporting framework. Experts reviewed the expanded audit methodology to determine its impact on performance monitoring and clinical reproducibility. The study scrutinized the updated characterization for digital breast tomosynthesis and revised calcification terminology. This systematic evaluation provides a clear overview of how the new standards influence interpretation and multidisciplinary communication.
Main Results:
Key Findings From the Literature indicate that the updated manual improves reporting consistency and reproducibility across the full spectrum of breast imaging. The authors report that the framework now includes structured clinical indication categories and refined morphologic descriptors to harmonize findings. The study highlights the introduction of BI-RADS 4 subclassification for breast MRI to mirror other modalities. Results demonstrate that the manual formally incorporates contrast-enhanced mammography into the standard reporting structure. The findings show that revised calcification terminology and new descriptors for nonmass lesions enhance ultrasound interpretation. The authors note that the inclusion of enhancement and T2-related descriptors improves the characterization of MRI findings. The analysis confirms that the updated audit methodology supports more robust performance monitoring for clinical practices. The evidence suggests that these changes successfully preserve core principles while modernizing the linkage between imaging findings and management recommendations.
Conclusions:
The authors propose that the updated manual enhances reporting consistency across all breast imaging modalities. Synthesis and implications suggest that standardized terminology will improve communication within multidisciplinary teams. Researchers emphasize that refined assessment categories provide clearer guidance for clinical management decisions. The review highlights that the new framework supports better performance monitoring through expanded audit methodologies. Authors claim that the integration of contrast-enhanced mammography formalizes its role in standard diagnostic workflows. The evidence indicates that structured lesion localization and tissue composition assessment reduce ambiguity in clinical reports. Experts note that these changes preserve the core principles of evidence-based assessment while modernizing the overall reporting structure. The findings suggest that these updates will facilitate more reliable correlation of findings across different imaging technologies.
The researchers propose that the updated framework improves reporting consistency and reproducibility by standardizing terminology across mammography, ultrasound, MRI, and contrast-enhanced mammography. This approach ensures that assessment categories are applied uniformly, regardless of the specific imaging modality utilized during the diagnostic process.
The authors introduce structured clinical indication categories and refined morphologic descriptors. These components are designed to harmonize reporting practices, ensuring that clinicians use consistent language when describing findings such as nonmass lesions or specific calcification patterns across different platforms.
The researchers explain that subclassification for breast MRI is now required to mirror other modalities. This technical necessity ensures that assessment categories remain comparable across the full spectrum of breast imaging, allowing for more reliable performance monitoring and auditability.
The authors utilize this data type to formalize its role within the reporting framework. By incorporating specific enhancement and T2-related descriptors, the manual ensures that findings from this modality are integrated into the broader clinical assessment process.
The researchers highlight that the manual now includes refined characterization for digital breast tomosynthesis. This measurement allows for more precise identification of findings, which helps clinicians distinguish between benign and malignant features more effectively than in previous versions.
The authors claim that these updates will improve multidisciplinary communications and auditability. By providing a more structured approach to reporting, the system enables better performance monitoring and ensures that imaging findings are clearly linked to appropriate management recommendations.