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Updated: Jun 4, 2026

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
Published on: December 23, 2022
Myocardial Infarction With Normal Coronary Arteries in 2 Patients With Patent Foramen Ovale
Eustaquio M Onorato1, Luca Grancini1, Francesco Casilli2
1University Cardiology Department, I.R.C.C.S. Ospedale Galeazzi-Sant'Ambrogio, Milan, Italy.
Paradoxical coronary artery embolism (PCAE) can cause acute coronary events in young adults. A patent foramen ovale (PFO) may be the underlying cause in patients with normal coronary arteries.
Area of Science:
- Cardiology
- Vascular Medicine
- Pathophysiology
Background:
- Paradoxical coronary artery embolism (PCAE) accounts for a significant portion of acute coronary events in individuals under 35.
- Patent foramen ovale (PFO) is a potential, often overlooked, cause of PCAE.
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