Spectrally Resolved (Colour-Coded) Fundus Autofluorescence Using the EIDON System in Vitreoretinal Lymphoma

Area of Science:

• Ophthalmology
• Medical Imaging
• Oncology

Background:

• Vitreoretinal lymphoma (VRL) presents diagnostic challenges due to varied ocular manifestations.
• Accurate diagnosis of VRL is crucial for timely treatment and improved patient outcomes.

Purpose of the Study:

• To evaluate the efficacy of colour-coded fundus autofluorescence (FAF) in diagnosing VRL.
• To compare colour-coded FAF with conventional blue and green FAF for detecting VRL lesions.

Main Methods:

• Retrospective analysis of 20 eyes from 10 VRL patients using colour-coded FAF.
• Comparative analysis with blue and green FAF, and optical coherence tomography.
• Assessment of lesion detection and appearance in macular and extramacular locations.

Main Results:

• Excellent inter-reader agreement for VRL lesion detection with colour-coded FAF.
• Colour-coded FAF superiorly identified retinitis-like lesions and lymphomatous RPE detachments versus blue/green FAF.
• Colour-coded FAF detected minor fluorophores, RPE atrophic areas, sub-RPE deposits, and perivascular infiltrates.

Conclusions:

• Colour-coded FAF effectively recognizes classic VRL features.
• This imaging modality aids in identifying subtle VRL manifestations like retinitis-like lesions and RPE detachments.
• Colour-coded FAF serves as a valuable complementary tool for VRL diagnosis.