Related Experiment Video

Updated: Jul 25, 2026

Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test
08:58

Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test

Published on: April 30, 2019

Rubella in Jerusalem. 2. Clinical and serologic findings in children with congenital rubella

M Isacsohn, M Nishmi, T A Swartz

    Israel Journal of Medical Sciences
    |January 1, 1979
    PubMed

    Insights

    Congenital rubella syndrome can cause serious health issues in infants, even if the mother

    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Immunology

    Background:

    • Congenital rubella syndrome (CRS) results from maternal rubella infection during pregnancy.
    • Clinical and serologic evidence of CRS was observed in infants, with varying degrees of severity.
    • Maternal rubella infection can be symptomatic or asymptomatic during pregnancy.

    Purpose of the Study:

    • To investigate the long-term clinical manifestations of congenital rubella syndrome.
    • To identify the prevalence of symptomatic versus asymptomatic maternal rubella in CRS cases.
    • To highlight the importance of rubella immunization for pregnant women.

    Main Methods:

    • A three-year follow-up study of 48 infants diagnosed with congenital rubella syndrome.
    • Clinical assessment for expanded rubella syndrome, multiple anomalies, and single defects.
    • Serologic testing to monitor antibody levels and identify asymptomatic maternal infections.

    Main Results:

    • Congenital rubella syndrome manifestations, including expanded rubella syndrome and anomalies, were observed primarily in the first year of life.
    • New health problems emerged later in some initially healthy children with high rubella antibody levels.
    • Maternal rubella was asymptomatic in 69% of cases, underscoring the challenge of early detection.

    Conclusions:

    • Congenital rubella syndrome can lead to significant and varied health issues in children.
    • Asymptomatic maternal rubella poses a substantial risk for congenital rubella syndrome.
    • Pre-pregnancy identification and immunization of seronegative women are crucial for preventing congenital rubella syndrome.

    More Related Videos

    Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis08:44

    Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

    Published on: September 7, 2022

    Detection of Rabies IgG and IgM Antibodies Using the Rabies Indirect Fluorescent Antibody Test07:54

    Detection of Rabies IgG and IgM Antibodies Using the Rabies Indirect Fluorescent Antibody Test

    Published on: January 19, 2024

    Related Concept Videos

    Rh Blood Group01:19

    Rh Blood Group

    The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
    Development of Immunocompetence01:22

    Development of Immunocompetence

    The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
    The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
    Subsequent T...
    Endocarditis II: Clinical Features of Infective Endocarditis01:25

    Endocarditis II: Clinical Features of Infective Endocarditis

    Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
    Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

    Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

    The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
    Cytomegalovirus Disease01:27

    Cytomegalovirus Disease

    Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
    Respiratory Syncytial Virus Disease01:29

    Respiratory Syncytial Virus Disease

    Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...