Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A computational framework to predict the spreading of Alzheimer's disease.

Engineering with computers·2026
Same author

Alzheimer's Disease Accelerates Cerebral Atrophy by Over a Decade Compared to Healthy Aging.

Annals of biomedical engineering·2026
Same author

Region-dependent mechanical parameters in simulating cerebral atrophy.

APL bioengineering·2026
Same author

A Physics-Informed Deep Learning Deformable Medical Image Registration Method Based on Neural ODEs.

International journal of computer vision·2025
Same author

Microindentation reveals softening of the equatorial and anterior sclera during early myopia development in tree shrew eyes.

Acta biomaterialia·2025
Same author

Insights into the Mechanical Characterization of Mouse Brain Tissue Using Microindentation Testing.

Current protocols·2024

Related Experiment Video

Updated: Jun 4, 2026

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
15:26

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

Published on: May 19, 2015

Aging-related lateral ventricular shape changes and corresponding mechanical loading derived from longitudinal image

Lauren Cunniff1,2,3, Johannes Weickenmeier4,5,6,

  • 1Department of Mechanical Engineering, Stevens Institute of Technology, Hoboken, NJ, 07030, USA.

Biomechanics and Modeling in Mechanobiology
|June 3, 2026
PubMed
Summary

Aging brains show enlarged lateral ventricles, with mechanical stress concentrating at edges and atrium. This localized stress links to white matter degeneration and cognitive decline, offering new insights into brain aging.

Keywords:
Longitudinal nonlinear image registrationVentricular enlargementVentricular shape changeVentricular wall loadingWhite matter hyperintensities

More Related Videos

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse
08:12

Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse

Published on: August 30, 2022

Related Experiment Videos

Last Updated: Jun 4, 2026

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
15:26

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

Published on: May 19, 2015

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse
08:12

Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse

Published on: August 30, 2022

Area of Science:

  • Neuroimaging
  • Biomechanics
  • Gerontology

Background:

  • Lateral ventricular enlargement is a key feature of brain aging, accelerating in neurodegenerative diseases.
  • Current understanding of age-related ventricular shape changes and mechanical loads is limited.

Purpose of the Study:

  • To develop a framework for quantifying mechanical loads on the ventricular wall during aging.
  • To investigate the relationship between ventricular mechanical loading and periventricular white matter changes.

Main Methods:

  • Utilized nonlinear registration to analyze brain deformations from longitudinal MRI scans.
  • Mapped warp fields to a ventricular surface template to quantify mechanical loading (displacement, curvature, strain).
  • Analyzed data from 50 cognitively normal subjects (aged 70-75) from the Alzheimer's Disease Neuroimaging Initiative.

Main Results:

  • Observed mostly uniform ventricular expansion, but with distinct regions of high mechanical loading at ventricular edges and atrium.
  • Elevated mechanical loading spatially corresponded with periventricular white matter hyperintensities.
  • Mechanomarkers showed increased magnitudes with white matter hyperintensity burden, particularly curvature change.

Conclusions:

  • Age-related ventricular enlargement involves localized mechanical stresses.
  • These stresses are linked to periventricular white matter degeneration.
  • Mechanical loading associated with ventricular changes may contribute to cognitive decline.