Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcatheter Mitral Valve-in-Valve Replacement With Microaxial Flow-Pump Support for Bioprosthetic Valve Failure.

JACC. Case reports·2026
Same author

Combining Renal Autotransplantation and Endovascular Aortic Repair for Abdominal Aortic Aneurysm in an LVAD Patient.

JACC. Case reports·2026
Same author

Erratum to 2025 American Association for Thoracic Surgery (AATS) Expert Consensus Document: Surgical management of acute myocardial infarction and associated complications: The Journal of Thoracic and Cardiovascular Surgery, Volume 170, Issue 5, 2025, Pages 1327-1344.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Machine Learning Based Prediction of Hospital Mortality in Post-Cardiotomy Cardiogenic Shock with Mechanical Support.

ESC heart failure·2026
Same author

[Management of complications associated with cardiac device procedures].

Herzschrittmachertherapie & Elektrophysiologie·2026
Same author

Impact of Partial- to Full-Support Escalation With Microaxial Flow Pumps Prior to Durable Left Ventricular Assist Device Implantation.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026

Related Experiment Video

Updated: Jun 5, 2026

Laminectomy and Spinal Cord Window Implantation in the Mouse
06:59

Laminectomy and Spinal Cord Window Implantation in the Mouse

Published on: October 23, 2019

Local Anesthesia and Analgosedation for Surgical Micro-Axial Flow Pump Implantation.

Anika Nagel1,2, Gaik Nersesian1,2,3, Peter Fischer2,4

  • 1From the Deutsches Herzzentrum der Charité, Department of Cardiothoracic and Vascular Surgery, Berlin, Germany.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|June 3, 2026
PubMed
Summary

Surgical implantation of micro-axial flow pumps (mAFP) for cardiogenic shock is feasible with local anesthesia and sedation. This approach reduces risks associated with general anesthesia, showing promising results for patient management.

Keywords:
awake implantationcardiogenic shocklocal anesthesiamechanical circulatory supportmicro-axial flow pump

More Related Videos

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging
10:50

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging

Published on: June 29, 2013

Stereotaxic Surgery for Excitotoxic Lesion of Specific Brain Areas in the Adult Rat
12:45

Stereotaxic Surgery for Excitotoxic Lesion of Specific Brain Areas in the Adult Rat

Published on: July 19, 2012

Related Experiment Videos

Last Updated: Jun 5, 2026

Laminectomy and Spinal Cord Window Implantation in the Mouse
06:59

Laminectomy and Spinal Cord Window Implantation in the Mouse

Published on: October 23, 2019

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging
10:50

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging

Published on: June 29, 2013

Stereotaxic Surgery for Excitotoxic Lesion of Specific Brain Areas in the Adult Rat
12:45

Stereotaxic Surgery for Excitotoxic Lesion of Specific Brain Areas in the Adult Rat

Published on: July 19, 2012

Area of Science:

  • Cardiology
  • Cardiovascular Surgery
  • Critical Care Medicine

Background:

  • Temporary mechanical circulatory support is vital for cardiogenic shock.
  • General anesthesia for device implantation poses hemodynamic risks.
  • Local anesthesia with analgosedation presents a viable alternative for spontaneously breathing patients.

Purpose of the Study:

  • To evaluate the feasibility and safety of micro-axial flow pump (mAFP) implantation under local anesthesia and analgosedation.
  • To compare outcomes of mAFP implantation with local anesthesia versus traditional general anesthesia.

Main Methods:

  • Retrospective analysis of 374 patients undergoing surgical mAFP implantation (Jan 2023 - Dec 2024).
  • Focus on 50 patients who received mAFP under local anesthesia with analgosedation.
  • Data collected included patient demographics, shock etiology, preoperative status (catecholamines, lactate), SCAI Shock classification, and complications.

Main Results:

  • 13.4% (50/374) of mAFP implantations were performed under local anesthesia.
  • Investigated patients (n=49) were predominantly male (79.6%), median age 62 years.
  • Common shock etiologies included dilated (51.0%) and ischemic (26.5%) cardiomyopathy.
  • High preoperative support needs: 91.8% on catecholamines, median lactate 1.9 mmol/L.
  • SCAI stages C (49.0%) and D (38.8%) were prevalent.
  • Procedure-related complications were infrequent (6/49 patients).
  • Four patients (8.2%) required conversion to general anesthesia.

Conclusions:

  • Micro-axial flow pump implantation under analgosedation and local anesthesia is feasible.
  • This approach may offer a safer alternative to general anesthesia for select cardiogenic shock patients.
  • Further research is warranted to optimize patient selection and procedural protocols.