The Efficacy of Mumijo Extract in Protecting Against Amoxicillin/Clavulanate-Induced Apoptotic Damage in Renal...

Area of Science:

• Pharmacology
• Toxicology
• Nephrology

Background:

• Amoxicillin/Clavulanate (A/C) antibiotic therapy can cause kidney damage via oxidative stress and apoptosis.
• Mumijo extract (PS) possesses antioxidant and anti-inflammatory properties, suggesting potential protective effects.
• Investigating PS efficacy against A/C-induced nephrotoxicity is crucial for managing drug-induced kidney injury.

Purpose of the Study:

• To evaluate the protective effects of Mumijo extract (PS) against amoxicillin/clavulanate (A/C)-induced renal damage in a rat model.
• To assess the impact of PS on oxidative stress markers, apoptosis, and renal function following A/C administration.
• To determine the potential of PS as a therapeutic intervention for drug-induced nephrotoxicity.

Main Methods:

• Wistar albino rats were divided into four groups: Sham, A/C, PS, and A/C+PS, treated orally for 21 days.
• Evaluated renal function (urea, creatinine), oxidative stress (TAS, TOS, MDA), and histopathology.
• Assessed apoptosis markers (Bax, Bcl-2 protein expression) to quantify cellular damage.

Main Results:

• A/C significantly elevated urea, creatinine, TOS, and MDA, while decreasing TAS, indicating kidney damage and oxidative stress.
• Histopathology showed tubular damage and inflammation in A/C-treated rats.
• PS supplementation in the A/C+PS group reversed these effects, improving TAS, reducing oxidative stress, enhancing histopathology, and modulating apoptosis markers (increased Bcl-2, decreased Bax).

Conclusions:

• Mumijo extract (PS) effectively mitigates amoxicillin/clavulanate (A/C)-induced oxidative stress and renal apoptosis.
• PS preserves renal tissue integrity and function, suggesting its potential as a therapeutic agent for drug-induced nephrotoxicity.
• PS demonstrates a favorable safety profile, with no adverse effects observed when administered alone.